Endocrine Abstracts

A 22-year old female diagnosed with thyrotoxicosis with raised free thryroxine (16.8 pmol/l) and suppressed thyroid-stimulating-hormone (TSH<0.03 mIU/l). She was started on Carbimazole 20 mg during end of August 2011. A fortnight later she presented with nausea, vomiting, fever and rigors. Her renal functions were deranged with a creatinine of 704 μmol/l, which worsened over the next 48 h. She subsequently needed renal replacement therapy with haemodialysis. She was c...

A 74-year-old diabetic lady presented to emergency-department following a collapse due to hypoglycaemia (blood glucose 1.7 mmol/l) and responded dramatically to intravenous–glucose. She had recurrent hypoglycaemic episodes in the last-fortnight, despite discontinuation of her oral hypoglycaemics and no other obvious precipitating factors/toxins like alcohol. She was on prednisolone, 10 mg along with azathioprine, 150 mg, atenolol, 25 mg, and candesartan, 8 mg. She has rhe...

Background: Programmed disruption of the methionine cycle elevates plasma homocysteine concentrations leading to cardiovascular disease (CVD). Elements of this cycle are glucocorticoid responsive. Here we measured plasma cortisol, cysteine, homocysteine, glutathione and its breakdown product cysteinyl-glycine in the fed and fasted state in sheep....

IntroductionHypercalcemia is a recognised feature of parathyroid and neoplastic disorders and similarly erythrocytosis is recognised in some benign and malignant neoplasm.Case reportA 71-year-old man presented to the admissions unit with an episode of collapse. No significant neurological or cardiovascular cause was identified. The results of his routine investigation revealed haemoglobin of 19.7g/dl and a ...

The 1997 working party recommendations for the management of patients with pituitary tumours suggest formal assessment by an endocrinologist prior to tertiary referral. We have examined the extent of endocrine assessment in such patients performed both by endocrine and non-endocrine specialists in a large district general hospital. Using ICD 9 & 10 coding records on patients discharged between 1993 and 2000, we identified 60 patients with pituitary pathology. Of these, 1...

The corepressor NCOR2/SMRT regulates multiple nuclear receptors (NRs) and other transcription factors. Disruption to these functions are implicated in prostate cancer (PCa) progression but the details remain enigmatic. Therefore we sought to define the global functions of NCOR2/SMRT using isogenic PCa cell models, PCa mouse models and human PCa cohorts.We mapped the NCOR2 dependent transcriptome (RNA-seq), miRnome (miRNA-seq), methylome (EPIC methylation...